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<td id="blast-threshold">The expectation value (E) threshold is a statistical measure of the number of expected matches in a random database. The lower the e-value, the more likely the match is to be significant. E-values between 0.1 and 10 are generally dubious, and over 10 are unlikely to have biological significance. In all cases, those matches need to be verified manually. You may need to increase the E threshold if you have a very short query sequence, to detect very weak similarities, or similarities in a short region, or if your sequence has a low complexity region and you use the "filter" option</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>E-Thresholdi

<td id="blast-matrix">The matrix assigns a probability score for each position in an alignment. The BLOSUM matrix assigns a probability score for each position in an alignment that is based on the frequency with which that substitution is known to occur among consensus blocks within related proteins. BLOSUM62 is among the best of the available matrices for detecting weak protein similarities. The PAM set of matrices is also available. If "Auto" is set, the matrix will be selected depending on the query sequence length.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Matrixi

<td id="blast-filter">Low-complexity regions (e.g. stretches of cysteine in <a href="http://www.uniprot.org/uniprot/Q03751">Q03751</a>, or hydrophobic regions in membrane proteins) tend to produce spurious, insignificant matches with sequences in the database which have the same kind of low-complexity regions, but are unrelated biologically. If "Filter low complexity regions" is selected, the query sequence will be run through the program SEG, and all amino acids in low-complexity regions will be replaced by X's. </td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Filteringi

<td id="blast-gapped">This will allow gaps to be introduced in the sequences when the comparison is done.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Gappedi

<td id="blast-numal">Limits the number of returned alignments.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Hitsi

Sequence feature

Entry & position(s)O15397[6 - 6]
Description
Feature keyNatural variant
Feature identifierVAR_055118
        10         20         30         40         50
MDLNRIIQAL KGTIDPKLRI AAENELNQSY KIINFAPSLL RIIVSDHVEF
60 70 80 90 100
PVRQAAAIYL KNMVTQYWPD REPPPGEAIF PFNIHENDRQ QIRDNIVEGI
110 120 130 140 150
IRSPDLVRVQ LTMCLRAIIK HDFPGHWPGV VDKIDYYLQS QSSASWLGSL
160 170 180 190 200
LCLYQLVKTY EYKKAEEREP LIIAMQIFLP RIQQQIVQLL PDSSYYSVLL
210 220 230 240 250
QKQILKIFYA LVQYALPLQL VNNQTMTTWM EIFRTIIDRT VPPETLHIDE
260 270 280 290 300
DDRPELVWWK CKKWALHIVA RLFERYGSPG NVTKEYFEFS EFFLKTYAVG
310 320 330 340 350
IQQVLLKILD QYRQKEYVAP RVLQQAFNYL NQGVVHSITW KQMKPHIQNI
360 370 380 390 400
SEDVIFSVMC YKDEDEELWQ EDPYEYIRMK FDIFEDYASP TTAAQTLLYT
410 420 430 440 450
AAKKRKEVLP KMMAFCYQIL TDPNFDPRKK DGALHVIGSL AEILLKKSLF
460 470 480 490 500
KDQMELFLQN HVFPLLLSNL GYLRARSCWV LHAFSSLKFH NELNLRNAVE
510 520 530 540 550
LAKKSLIEDK EMPVKVEAAL ALQSLISNQI QAKEYMKPHV RPIMQELLHI
560 570 580 590 600
VRETENDDVT NVIQKMICEY SQEVASIAVD MTQHLAEIFG KVLQSDEYEE
610 620 630 640 650
VEDKTVMAMG ILHTIDTILT VVEDHKEITQ QLENICLRII DLVLQKHVIE
660 670 680 690 700
FYEEILSLAY SLTCHSISPQ MWQLLGILYE VFQQDCFEYF TDMMPLLHNY
710 720 730 740 750
VTIDTDTLLS NAKHLEILFT MCRKVLCGDA GEDAECHAAK LLEVIILQCK
760 770 780 790 800
GRGIDQCIPL FVQLVLERLT RGVKTSELRT MCLQVAIAAL YYNPDLLLHT
810 820 830 840 850
LERIQLPHNP GPITVQFINQ WMNDTDCFLG HHDRKMCIIG LSILLELQNR
860 870 880 890 900
PPAVDAVVGQ IVPSILFLFL GLKQVCATRQ LVNREDRSKA EKADMEENEE
910 920 930 940 950
ISSDEEETNV TAQAMQSNNG RGEDEEEEDD DWDEEVLEET ALEGFSTPLD
960 970 980 990 1000
LDNSVDEYQF FTQALITVQS RDAAWYQLLM APLSEDQRTA LQEVYTLAEH
1010 1020 1030
RRTVAEAKKK IEQQGGFTFE NKGVLSAFNF GTVPSNN
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Main funding by: National Institutes of Health

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