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<td id="blast-threshold">The expectation value (E) threshold is a statistical measure of the number of expected matches in a random database. The lower the e-value, the more likely the match is to be significant. E-values between 0.1 and 10 are generally dubious, and over 10 are unlikely to have biological significance. In all cases, those matches need to be verified manually. You may need to increase the E threshold if you have a very short query sequence, to detect very weak similarities, or similarities in a short region, or if your sequence has a low complexity region and you use the "filter" option</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>E-Thresholdi

<td id="blast-matrix">The matrix assigns a probability score for each position in an alignment. The BLOSUM matrix assigns a probability score for each position in an alignment that is based on the frequency with which that substitution is known to occur among consensus blocks within related proteins. BLOSUM62 is among the best of the available matrices for detecting weak protein similarities. The PAM set of matrices is also available. If "Auto" is set, the matrix will be selected depending on the query sequence length.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Matrixi

<td id="blast-filter">Low-complexity regions (e.g. stretches of cysteine in <a href="http://www.uniprot.org/uniprot/Q03751">Q03751</a>, or hydrophobic regions in membrane proteins) tend to produce spurious, insignificant matches with sequences in the database which have the same kind of low-complexity regions, but are unrelated biologically. If "Filter low complexity regions" is selected, the query sequence will be run through the program SEG, and all amino acids in low-complexity regions will be replaced by X's. </td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Filteringi

<td id="blast-gapped">This will allow gaps to be introduced in the sequences when the comparison is done.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Gappedi

<td id="blast-numal">Limits the number of returned alignments.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Hitsi

Sequence feature

Entry & position(s)O18866[210 - 213]
Description
Feature keyTopological domain
Feature identifier
        10         20         30         40         50
MSSNIHANHL SLDASSSSSS SSSSSSSSSS SSSSVHEPKM DALIIPVTME
60 70 80 90 100
VPCDSRGQRM WWAFLASSMV TFFGGLFIIL LWRTLKYLWT VCCHCGGKTK
110 120 130 140 150
EAQKINNGAS QADGTLKPVD EKEEVVAAEV GWMTSVKDWA GVMISAQTLT
160 170 180 190 200
GRVLVVLVFA LSIGALVIYF IDSSNPIESC QNFYKDFTLQ IDMAFNVFFL
210 220 230 240 250
LYFGLRFIAA NDKLWFWLEV NSVVDFFTVP PVFVSVYLNR SWLGLRFLRA
260 270 280 290 300
LRLIQFSEIL QFLNILKTSN SIKLVNLLSI FISTWLTAAG FIHLVENSGD
310 320 330 340 350
PWENFQNNQA LTYWECVYLL MVTMSTVGYG DVYAKTTLGR LFMVFFILGG
360 370 380 390 400
LAMFASYVPE IIELIGNRKK YGGSYSAVSG RKHIVVCGHI TLESVSNFLK
410 420 430 440 450
DFLHKDRDDV NVEIVFLHNI SPNLELEALF KRHFTQVEFY QGSVLNPHDL
460 470 480 490 500
ARVKIESADA CLILANKYCA DPDAEDASNI MRVISIKNYH PKIRIITQML
510 520 530 540 550
QYHNKAHLLN IPSWNWKEGD DAICLAELKL GFIAQSCLAQ GLSTMLANLF
560 570 580 590 600
SMRSFIKIEE DTWQKYYLEG VSNEMYTEYL SSAFVGLSFP TVCELCFVKL
610 620 630 640 650
KLLMIAIEYK SANRESRILI NPGNHLKIQE GTLGFFIASD AKEVKRAFFY
660 670 680 690 700
CKACHDDITD PKRIKKCGCK RLEDEQPSTL SPKKKQRNGG MRNSPSSSPK
710 720 730 740 750
LMRHDPLLIP GNDQIDNMDS NVKKYDSTGM FHWCAPKEIE KVILTRSEAA
760 770 780 790 800
MTVLSGHVVV CIFGDVSSAL IGLRNLVMPL RASNFHYHEL KHIVFVGSIE
810 820 830 840 850
YLKREWETLH NFPKVSILPG TPLSRADLRA VNINLCDMCV ILSANQNNID
860 870 880 890 900
DTSLQDKECI LASLNIKSMQ FDDSIGVLQA NSQGFTPPGM DRSSPDNSPV
910 920 930 940 950
HGMLRQPSIT TGVNIPIITE LVNDTNVQFL DQDDDDDPDT ELYLTQPFAC
960 970 980 990 1000
GTAFAVSVLD SLMSATYFND NILTLIRTLV TGGATPELEA LIAEENALRG
1010 1020 1030 1040 1050
GYSTPQTLAN RDRCRVAQLA LLDGPFADLG DGGCYGDLFC KALKTYNMLC
1060 1070 1080 1090 1100
FGIYRLRDAH LSTPSQCTKR YVITNPPYEF ELVPTDLIFC LMQFDHNAGQ
1110 1120 1130 1140 1150
SRASLSHSSH SSQSSSKKSS SVHSIPSTAN RQNRPKSRES RDKQKYVQEE

RL
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