Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

<td id="blast-threshold">The expectation value (E) threshold is a statistical measure of the number of expected matches in a random database. The lower the e-value, the more likely the match is to be significant. E-values between 0.1 and 10 are generally dubious, and over 10 are unlikely to have biological significance. In all cases, those matches need to be verified manually. You may need to increase the E threshold if you have a very short query sequence, to detect very weak similarities, or similarities in a short region, or if your sequence has a low complexity region and you use the "filter" option</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>E-Thresholdi

<td id="blast-matrix">The matrix assigns a probability score for each position in an alignment. The BLOSUM matrix assigns a probability score for each position in an alignment that is based on the frequency with which that substitution is known to occur among consensus blocks within related proteins. BLOSUM62 is among the best of the available matrices for detecting weak protein similarities. The PAM set of matrices is also available. If "Auto" is set, the matrix will be selected depending on the query sequence length.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Matrixi

<td id="blast-filter">Low-complexity regions (e.g. stretches of cysteine in <a href="http://www.uniprot.org/uniprot/Q03751">Q03751</a>, or hydrophobic regions in membrane proteins) tend to produce spurious, insignificant matches with sequences in the database which have the same kind of low-complexity regions, but are unrelated biologically. If "Filter low complexity regions" is selected, the query sequence will be run through the program SEG, and all amino acids in low-complexity regions will be replaced by X's. </td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Filteringi

<td id="blast-gapped">This will allow gaps to be introduced in the sequences when the comparison is done.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Gappedi

<td id="blast-numal">Limits the number of returned alignments.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Hitsi

Sequence feature

Entry & position(s)P25054-2
Description
Feature key
Feature identifier
        10         20         30         40         50
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ
60 70 80 90 100
LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE
110 120 130 140 150
GSVSSRSGEC SPVPMGSFPR RGFVNGSRES TGYLEELEKE RSLLLADLDK
160 170 180 190 200
EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE YEARQIRVAM
210 220 230 240 250
EEQLGTCQDM EKRAQRRIAR IQQIEKDILR IRQLLQSQAT EAERSSQNKH
260 270 280 290 300
ETGSHDAERQ NEGQGVGEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA
310 320 330 340 350
PRRLTSHLGT KIRAYCETCW EWQEAHEPGM DQDKNPMPAP VEHQICPAVC
360 370 380 390 400
VLMKLSFDEE HRHAMNELGG LQAIAELLQV DCEMYGLTND HYSITLRRYA
410 420 430 440 450
GMALTNLTFG DVANKATLCS MKGCMRALVA QLKSESEDLQ QVIASVLRNL
460 470 480 490 500
SWRADVNSKK TLREVGSVKA LMECALEVKK ESTLKSVLSA LWNLSAHCTE
510 520 530 540 550
NKADICAVDG ALAFLVGTLT YRSQTNTLAI IESGGGILRN VSSLIATNED
560 570 580 590 600
HRQILRENNC LQTLLQHLKS HSLTIVSNAC GTLWNLSARN PKDQEALWDM
610 620 630 640 650
GAVSMLKNLI HSKHKMIAMG SAAALRNLMA NRPAKYKDAN IMSPGSSLPS
660 670 680 690 700
LHVRKQKALE AELDAQHLSE TFDNIDNLSP KASHRSKQRH KQSLYGDYVF
710 720 730 740 750
DTNRHDDNRS DNFNTGNMTV LSPYLNTTVL PSSSSSRGSL DSSRSEKDRS
760 770 780 790 800
LERERGIGLG NYHPATENPG TSSKRGLQIS TTAAQIAKVM EEVSAIHTSQ
810 820 830 840 850
EDRSSGSTTE LHCVTDERNA LRRSSAAHTH SNTYNFTKSE NSNRTCSMPY
860 870 880 890 900
AKLEYKRSSN DSLNSVSSSD GYGKRGQMKP SIESYSEDDE SKFCSYGQYP
910 920 930 940 950
ADLAHKIHSA NHMDDNDGEL DTPINYSLKY SDEQLNSGRQ SPSQNERWAR
960 970 980 990 1000
PKHIIEDEIK QSEQRQSRNQ STTYPVYTES TDDKHLKFQP HFGQQECVSP
1010 1020 1030 1040 1050
YRSRGANGSE TNRVGSNHGI NQNVSQSLCQ EDDYEDDKPT NYSERYSEEE
1060 1070 1080 1090 1100
QHEEEERPTN YSIKYNEEKR HVDQPIDYSL KYATDIPSSQ KQSFSFSKSS
1110 1120 1130 1140 1150
SGQSSKTEHM SSSSENTSTP SSNAKRQNQL HPSSAQSRSG QPQKAATCKV
1160 1170 1180 1190 1200
SSINQETIQT YCVEDTPICF SRCSSLSSLS SAEDEIGCNQ TTQEADSANT
1210 1220 1230 1240 1250
LQIAEIKEKI GTRSAEDPVS EVPAVSQHPR TKSSRLQGSS LSSESARHKA
1260 1270 1280 1290 1300
VEFSSGAKSP SKSGAQTPKS PPEHYVQETP LMFSRCTSVS SLDSFESRSI
1310 1320 1330 1340 1350
ASSVQSEPCS GMVSGIISPS DLPDSPGQTM PPSRSKTPPP PPQTAQTKRE
1360 1370 1380 1390 1400
VPKNKAPTAE KRESGPKQAA VNAAVQRVQV LPDADTLLHF ATESTPDGFS
1410 1420 1430 1440 1450
CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PKESNENQEK
1460 1470 1480 1490 1500
EAEKTIDSEK DLLDDSDDDD IEILEECIIS AMPTKSSRKA KKPAQTASKL
1510 1520 1530 1540 1550
PPPVARKPSQ LPVYKLLPSQ NRLQPQKHVS FTPGDDMPRV YCVEGTPINF
1560 1570 1580 1590 1600
STATSLSDLT IESPPNELAA GEGVRGGAQS GEFEKRDTIP TEGRSTDEAQ
1610 1620 1630 1640 1650
GGKTSSVTIP ELDDNKAEEG DILAECINSA MPKGKSHKPF RVKKIMDQVQ
1660 1670 1680 1690 1700
QASASSSAPN KNQLDGKKKK PTSPVKPIPQ NTEYRTRVRK NADSKNNLNA
1710 1720 1730 1740 1750
ERVFSDNKDS KKQNLKNNSK VFNDKLPNNE DRVRGSFAFD SPHHYTPIEG
1760 1770 1780 1790 1800
TPYCFSRNDS LSSLDFDDDD VDLSREKAEL RKAKENKESE AKVTSHTELT
1810 1820 1830 1840 1850
SNQQSANKTQ AIAKQPINRG QPKPILQKQS TFPQSSKDIP DRGAATDEKL
1860 1870 1880 1890 1900
QNFAIENTPV CFSHNSSLSS LSDIDQENNN KENEPIKETE PPDSQGEPSK
1910 1920 1930 1940 1950
PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE CISSAMPKKK
1960 1970 1980 1990 2000
KPSRLKGDNE KHSPRNMGGI LGEDLTLDLK DIQRPDSEHG LSPDSENFDW
2010 2020 2030 2040 2050
KAIQEGANSI VSSLHQAAAA ACLSRQASSD SDSILSLKSG ISLGSPFHLT
2060 2070 2080 2090 2100
PDQEEKPFTS NKGPRILKPG EKSTLETKKI ESESKGIKGG KKVYKSLITG
2110 2120 2130 2140 2150
KVRSNSEISG QMKQPLQANM PSISRGRTMI HIPGVRNSSS STSPVSKKGP
2160 2170 2180 2190 2200
PLKTPASKSP SEGQTATTSP RGAKPSVKSE LSPVARQTSQ IGGSSKAPSR
2210 2220 2230 2240 2250
SGSRDSTPSR PAQQPLSRPI QSPGRNSISP GRNGISPPNK LSQLPRTSSP
2260 2270 2280 2290 2300
STASTKSSGS GKMSYTSPGR QMSQQNLTKQ TGLSKNASSI PRSESASKGL
2310 2320 2330 2340 2350
NQMNNGNGAN KKVELSRMSS TKSSGSESDR SERPVLVRQS TFIKEAPSPT
2360 2370 2380 2390 2400
LRRKLEESAS FESLSPSSRP ASPTRSQAQT PVLSPSLPDM SLSTHSSVQA
2410 2420 2430 2440 2450
GGWRKLPPNL SPTIEYNDGR PAKRHDIARS HSESPSRLPI NRSGTWKREH
2460 2470 2480 2490 2500
SKHSSSLPRV STWRRTGSSS SILSASSESS EKAKSEDEKH VNSISGTKQS
2510 2520 2530 2540 2550
KENQVSAKGT WRKIKENEFS PTNSTSQTVS SGATNGAESK TLIYQMAPAV
2560 2570 2580 2590 2600
SKTEDVWVRI EDCPINNPRS GRSPTGNTPP VIDSVSEKAN PNIKDSKDNQ
2610 2620 2630 2640 2650
AKQNVGNGSV PMRTVGLENR LNSFIQVDAP DQKGTEIKPG QNNPVPVSET
2660 2670 2680 2690 2700
NESSIVERTP FSSSSSSKHS SPSGTVAARV TPFNYNPSPR KSSADSTSAR
2710 2720 2730 2740
PSQIPTPVNN NTKKRDSKTD STESSGTQSP KRHSGSYLVT SV
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again