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<td id="blast-threshold">The expectation value (E) threshold is a statistical measure of the number of expected matches in a random database. The lower the e-value, the more likely the match is to be significant. E-values between 0.1 and 10 are generally dubious, and over 10 are unlikely to have biological significance. In all cases, those matches need to be verified manually. You may need to increase the E threshold if you have a very short query sequence, to detect very weak similarities, or similarities in a short region, or if your sequence has a low complexity region and you use the "filter" option</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>E-Thresholdi

<td id="blast-matrix">The matrix assigns a probability score for each position in an alignment. The BLOSUM matrix assigns a probability score for each position in an alignment that is based on the frequency with which that substitution is known to occur among consensus blocks within related proteins. BLOSUM62 is among the best of the available matrices for detecting weak protein similarities. The PAM set of matrices is also available. If "Auto" is set, the matrix will be selected depending on the query sequence length.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Matrixi

<td id="blast-filter">Low-complexity regions (e.g. stretches of cysteine in <a href="http://www.uniprot.org/uniprot/Q03751">Q03751</a>, or hydrophobic regions in membrane proteins) tend to produce spurious, insignificant matches with sequences in the database which have the same kind of low-complexity regions, but are unrelated biologically. If "Filter low complexity regions" is selected, the query sequence will be run through the program SEG, and all amino acids in low-complexity regions will be replaced by X's. </td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Filteringi

<td id="blast-gapped">This will allow gaps to be introduced in the sequences when the comparison is done.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Gappedi

<td id="blast-numal">Limits the number of returned alignments.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Hitsi

Sequence feature

Entry & position(s)P46100-3
Description
Feature key
Feature identifier
        10         20         30         40         50
MQSLPKGTVI VQPEPVLNED KDDFKGPEFR SRSKMKTENL KKRGEDGLHG
60 70 80 90 100
IVSCTACGQQ VNHFQKDSIY RHPSLQVLIC KNCFKYYMSD DISRDSDGMD
110 120 130 140 150
EQCRWCAEGG NLICCDFCHN AFCKKCILRN LGRKELSTIM DENNQWYCYI
160 170 180 190 200
CHPEPLLDLV TACNSVFENL EQLLQQNKKK IKVDSEKSNK VYEHTSRFSP
210 220 230 240 250
KKTSSNCNGE EKKLDDSCSG SVTYSYSALI VPKEMIKKAK KLIETTANMN
260 270 280 290 300
SSYVKFLKQA TDNSEISSAT KLRQLKAFKS VLADIKKAHL ALEEDLNSEF
310 320 330 340 350
RAMDAVNKEK NTKEHKVIDA KFETKARKGE KPCALEKKDI SKSEAKLSRK
360 370 380 390 400
QVDSEHMHQN VPTEEQRTNK STGGEHKKSD RKEEPQYEPA NTSEDLDMDI
410 420 430 440 450
VSVPSSVPED IFENLETAME VQSSVDHQGD GSSGTEQEVE SSSVKLNISS
460 470 480 490 500
KDNRGGIKSK TTAKVTKELY VKLTPVSLSN SPIKGADCQE VPQDKDGYKS
510 520 530 540 550
CGLNPKLEKC GLGQENSDNE HLVENEVSLL LEESDLRRSP RVKTTPLRRP
560 570 580 590 600
TETNPVTSNS DEECNETVKE KQKLSVPVRK KDKRNSSDSA IDNPKPNKLP
610 620 630 640 650
KSKQSETVDQ NSDSDEMLAI LKEVSRMSHS SSSDTDINEI HTNHKTLYDL
660 670 680 690 700
KTQAGKDDKG KRKRKSSTSG SDFDTKKGKS AKSSIISKKK RQTQSESSNY
710 720 730 740 750
DSELEKEIKS MSKIGAARTT KKRIPNTKDF DSSEDEKHSK KGMDNQGHKN
760 770 780 790 800
LKTSQEGSSD DAERKQERET FSSAEGTVDK DTTIMELRDR LPKKQQASAS
810 820 830 840 850
TDGVDKLSGK EQSFTSLEVR KVAETKEKSK HLKTKTCKKV QDGLSDIAEK
860 870 880 890 900
FLKKDQSDET SEDDKKQSKK GTEEKKKPSD FKKKVIKMEQ QYESSSDGTE
910 920 930 940 950
KLPEREEICH FPKGIKQIKN GTTDGEKKSK KIRDKTSKKK DELSDYAEKS
960 970 980 990 1000
TGKGDSCDSS EDKKSKNGAY GREKKRCKLL GKSSRKRQDC SSSDTEKYSM
1010 1020 1030 1040 1050
KEDGCNSSDK RLKRIELRER RNLSSKRNTK EIQSGSSSSD AEESSEDNKK
1060 1070 1080 1090 1100
KKQRTSSKKK AVIVKEKKRN SLRTSTKRKQ ADITSSSSSD IEDDDQNSIG
1110 1120 1130 1140 1150
EGSSDEQKIK PVTENLVLSS HTGFCQSSGD EALSKSVPVT VDDDDDDNDP
1160 1170 1180 1190 1200
ENRIAKKMLL EEIKANLSSD EDGSSDDEPE EGKKRTGKQN EENPGDEEAK
1210 1220 1230 1240 1250
NQVNSESDSD SEESKKPRYR HRLLRHKLTV SDGESGEEKK TKPKEHKEVK
1260 1270 1280 1290 1300
GRNRRKVSSE DSEDSDFQES GVSEEVSESE DEQRPRTRSA KKAELEENQR
1310 1320 1330 1340 1350
SYKQKKKRRR IKVQEDSSSE NKSNSEEEEE EKEEEEEEEE EEEEEEEDEN
1360 1370 1380 1390 1400
DDSKSPGKGR KKIRKILKDD KLRTETQNAL KEEEERRKRI AEREREREKL
1410 1420 1430 1440 1450
REVIEIEDAS PTKCPITTKL VLDEDEETKE PLVQVHRNMV IKLKPHQVDG
1460 1470 1480 1490 1500
VQFMWDCCCE SVKKTKKSPG SGCILAHCMG LGKTLQVVSF LHTVLLCDKL
1510 1520 1530 1540 1550
DFSTALVVCP LNTALNWMNE FEKWQEGLKD DEKLEVSELA TVKRPQERSY
1560 1570 1580 1590 1600
MLQRWQEDGG VMIIGYEMYR NLAQGRNVKS RKLKEIFNKA LVDPGPDFVV
1610 1620 1630 1640 1650
CDEGHILKNE ASAVSKAMNS IRSRRRIILT GTPLQNNLIE YHCMVNFIKE
1660 1670 1680 1690 1700
NLLGSIKEFR NRFINPIQNG QCADSTMVDV RVMKKRAHIL YEMLAGCVQR
1710 1720 1730 1740 1750
KDYTALTKFL PPKHEYVLAV RMTSIQCKLY QYYLDHLTGV GNNSEGGRGK
1760 1770 1780 1790 1800
AGAKLFQDFQ MLSRIWTHPW CLQLDYISKE NKGYFDEDSM DEFIASDSDE
1810 1820 1830 1840 1850
TSMSLSSDDY TKKKKKGKKG KKDSSSSGSG SDNDVEVIKV WNSRSRGGGE
1860 1870 1880 1890 1900
GNVDETGNNP SVSLKLEESK ATSSSNPSSP APDWYKDFVT DADAEVLEHS
1910 1920 1930 1940 1950
GKMVLLFEIL RMAEEIGDKV LVFSQSLISL DLIEDFLELA SREKTEDKDK
1960 1970 1980 1990 2000
PLIYKGEGKW LRNIDYYRLD GSTTAQSRKK WAEEFNDETN VRGRLFIIST
2010 2020 2030 2040 2050
KAGSLGINLV AANRVIIFDA SWNPSYDIQS IFRVYRFGQT KPVYVYRFLA
2060 2070 2080 2090 2100
QGTMEDKIYD RQVTKQSLSF RVVDQQQVER HFTMNELTEL YTFEPDLLDD
2110 2120 2130 2140 2150
PNSEKKKKRD TPMLPKDTIL AELLQIHKEH IVGYHEHDSL LDHKEEEELT
2160 2170 2180 2190 2200
EEERKAAWAE YEAEKKGLTM RFNIPTGTNL PPVSFNSQTP YIPFNLGALS
2210 2220 2230 2240 2250
AMSNQQLEDL INQGREKVVE ATNSVTAVRI QPLEDIISAV WKENMNLSEA
2260 2270 2280 2290 2300
QVQALALSRQ ASQELDVKRR EAIYNDVLTK QQMLISCVQR ILMNRRLQQQ
2310 2320 2330 2340 2350
YNQQQQQQMT YQQATLGHLM MPKPPNLIMN PSNYQQIDMR GMYQPVAGGM
2360 2370
QPPPLQRAPP PMRSKNPGPS QGKSM
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Main funding by: National Institutes of Health

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