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<td id="blast-threshold">The expectation value (E) threshold is a statistical measure of the number of expected matches in a random database. The lower the e-value, the more likely the match is to be significant. E-values between 0.1 and 10 are generally dubious, and over 10 are unlikely to have biological significance. In all cases, those matches need to be verified manually. You may need to increase the E threshold if you have a very short query sequence, to detect very weak similarities, or similarities in a short region, or if your sequence has a low complexity region and you use the "filter" option</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>E-Thresholdi

<td id="blast-matrix">The matrix assigns a probability score for each position in an alignment. The BLOSUM matrix assigns a probability score for each position in an alignment that is based on the frequency with which that substitution is known to occur among consensus blocks within related proteins. BLOSUM62 is among the best of the available matrices for detecting weak protein similarities. The PAM set of matrices is also available. If "Auto" is set, the matrix will be selected depending on the query sequence length.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Matrixi

<td id="blast-filter">Low-complexity regions (e.g. stretches of cysteine in <a href="http://www.uniprot.org/uniprot/Q03751">Q03751</a>, or hydrophobic regions in membrane proteins) tend to produce spurious, insignificant matches with sequences in the database which have the same kind of low-complexity regions, but are unrelated biologically. If "Filter low complexity regions" is selected, the query sequence will be run through the program SEG, and all amino acids in low-complexity regions will be replaced by X's. </td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Filteringi

<td id="blast-gapped">This will allow gaps to be introduced in the sequences when the comparison is done.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Gappedi

<td id="blast-numal">Limits the number of returned alignments.</td><p><a href='/help/sequence-searches' target='_top'>More...</a></p>Hitsi

Sequence feature

Entry & position(s)Q8AYS8[281 - 294]
Description
Feature keyTopological domain
Feature identifier
        10         20         30         40         50
MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA
60 70 80 90 100
SSMVTFFGGL FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA
110 120 130 140 150
CKPTDEKEEN VAAEVGWMTS VKDWAGVMIS AQTLTGRVLV VLVFALSIGA
160 170 180 190 200
LVIYFIDSSN PIESCQNFYK DFTLQIDMAF NVFFLLYFGL RFIAANDKLW
210 220 230 240 250
FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ FSEILQFLNI
260 270 280 290 300
LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE
310 320 330 340 350
CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI
360 370 380 390 400
GNRKKYGGSY SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV
410 420 430 440 450
FLHNISPNLE LEALFKRHFT QVEFYQGSVL NPHDLARVKI ESADACLILA
460 470 480 490 500
NKYCADPDAE DASNIMRVIS IKNYHPKIRI ITQMLQYHNK AHLLNIPSWN
510 520 530 540 550
WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF IKIEEDTWQK
560 570 580 590 600
YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE
610 620 630 640 650
SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK
660 670 680 690 700
KCGCKRLEDE QPSTLSPKKK QRNGGMRNSP NSSPKLMRHD PLLIPGNEQI
710 720 730 740 750
DNMDANVKKY DSTGMFHWCP AKDIEKVILT RSEAAMTVLS GHVVVCIFGD
760 770 780 790 800
VKSALIGLRN LVMPLRASNF HYHELKHIVF VGSLEYLRRE WETLHNFPKV
810 820 830 840 850
SILPGTPLSR ADLRAVNINL CDMCVILSAN QNNIDDASLQ DKECILASLN
860 870 880 890 900
IKSMQFDDSI GVLQANSQGF TPPGMDRSSP DNSPVHGLLR QPSITTGANI
910 920 930 940 950
PIITELVNDS NVQFLDQDDD DDPDTELYLT QPFACGTAFA VSVLDSLMSA
960 970 980 990 1000
TYFNDNILTL IRTLVTGGAT PELEALIAEE NALRGGYSTP QTLANRDRCR
1010 1020 1030 1040 1050
VAQLALYDGP FADLGDGGCY GDLFCKALKT YNMLCFGIYR LRDAHLSTPS
1060 1070 1080 1090 1100
QCTKRYVITN PPYEFELVPT DLIFCLMQFD HNAGQSRASL SHSSHSSYSS
1110 1120 1130
SKKSSSVHSI PSTANRPNRT KTRDSREKQK YVQEDRL
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