| http://purl.uniprot.org/citations/10074346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074346 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure of fragment double-D from human fibrin has been solved in the presence and absence of the peptide ligands that simulate the two knobs exposed by the removal of fibrinopeptides A and B, respectively. All told, six crystal structures have been determined, three of which are reported here for the first time: namely, fragments D and double-D with the peptide GHRPam alone and double-D in the absence of any peptide ligand. Comparison of the structures has revealed a series of conformational changes that are brought about by the various knob-hole interactions. Of greatest interest is a moveable "flap" of two negatively charged amino acids (Glubeta397 and Aspbeta398) whose side chains are pinned back to the coiled coil with a calcium atom bridge until GHRPam occupies the beta-chain pocket. Additionally, in the absence of the peptide ligand GPRPam, GHRPam binds to the gamma-chain pocket, a new calcium-binding site being formed concomitantly."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi982626w"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi982626w"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Spraggon G."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Spraggon G."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Doolittle R.F."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Doolittle R.F."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Everse S.J."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Everse S.J."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Veerapandian L."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/author | "Veerapandian L."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/pages | "2941-2946"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/pages | "2941-2946"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/title | "Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/title | "Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide."xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/10074346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10074346 |
| http://purl.uniprot.org/citations/10074346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10074346 |