| http://purl.uniprot.org/citations/10074410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074410 | http://www.w3.org/2000/01/rdf-schema#comment | "Homodimeric bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor beta (TGF-beta) superfamily that induces bone formation and regeneration, and determines important steps during early stages of embryonic development in vertebrates and non-vertebrates. BMP-2 can interact with two types of receptor chains, as well as with proteins of the extracellular matrix and several regulatory proteins. We report here the crystal structure of human BMP-2 determined by molecular replacement and refined to an R-value of 24.2 % at 2.7 A resolution. A common scaffold of BMP-2, BMP-7 and the TGF-betas, i.e. the cystine-knot motif and two finger-like double-stranded beta-sheets, can be superimposed with r. m.s. deviations of around 1 A. In contrast to the TGF-betas, the structure of BMP-2 shows differences in the flexibility of the N terminus and the orientation of the central alpha-helix as well as two external loops at the fingertips with respect to the scaffold. This is also known from the BMP-7 model. Small secondary structure elements in the loop regions of BMP-2 and BMP-7 seem to be specific for the respective BMP-subgroup. Two identical helix-finger clefts and two distinct cavities located around the central 2-fold axis of the dimer show characteristic shapes, polarity and surface charges. The possible function of these specific features in the interaction of BMP-2 with its binding partners is discussed."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1999.2590"xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1999.2590"xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/author | "Huelsmeyer M."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/author | "Huelsmeyer M."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/author | "Sebald W."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/author | "Sebald W."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/author | "Scheufler C."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/author | "Scheufler C."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/pages | "103-115"xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/pages | "103-115"xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/title | "Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/title | "Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution."xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/10074410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10074410 |
| http://purl.uniprot.org/citations/10074410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10074410 |
| http://purl.uniprot.org/citations/10074410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10074410 |
| http://purl.uniprot.org/citations/10074410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10074410 |