| http://purl.uniprot.org/citations/10075736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10075736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10075736 | http://www.w3.org/2000/01/rdf-schema#comment | "The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. We have identified a novel transcript of the MDMX gene that is expressed in a variety of cell lines, and in particular, in growing and transformed cells. This transcript is identical to the published sequence yet it has a short internal deletion of 68 base pairs. This deletion produces a shift in the reading frame after codon 114, resulting in the inclusion of a stop codon at amino acid residue 127 (full-length MDMX is 489 residues). This truncated MDMX protein is termed MDMX-S ("short form"), represents only the p53-binding domain, and appears to bind p53 better than full-length MDMX. The MDMX-S protein can be detected in cell extracts and when overexpressed is much more effective than MDMX at inhibiting p53-mediated transcriptional activation and induction of apoptosis. Since MDMX-S lacks the central and carboxyl-terminal regions contained within full-length MDMX, it is likely to play a key role in the regulation of cell proliferation and apoptosis in a way distinct from MDMX."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.12.8299"xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.12.8299"xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Hall D.J."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Hall D.J."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Mercer W.E."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Mercer W.E."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Cho B."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Cho B."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Rallapalli R."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Rallapalli R."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Strachan G."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/author | "Strachan G."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/pages | "8299-8308"xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/pages | "8299-8308"xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/title | "A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/title | "A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity."xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10075736 | http://purl.uniprot.org/core/volume | "274"xsd:string |