| http://purl.uniprot.org/citations/10080941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10080941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10080941 | http://www.w3.org/2000/01/rdf-schema#comment | "The N-termini of members of the T-cell factor (Tcf) and lymphocyte-enhancement factor (Lef) protein families bind to beta-catenin, forming bipartite transcription factors which regulate expression of genes involved in organismal development and the growth of normal and malignant colon epithelium. Elevated levels of Tcf4:beta-catenin are found in colon tumor cells with mutations in the adenomatous polyposis coli (APC) gene. The elevated levels of Tcf4:beta-catenin result in increased transcription of genes, including c-myc, important for the growth of these tumor cells. Here we analyze the interaction between beta-catenin and Tcf4 and show that the N-terminal 53 amino acids of Tcf4 bind with high affinity to beta-catenin. We show that this high-affinity interaction involves multiple contact points including Tcf4 Asp-16, which is essential for beta-catenin binding. In addition to Tcf/Lef family members, beta-catenin binds to APC and cadherins. We found that the binding of beta-catenin to Tcf4, APC, or E-cadherin was mutually exclusive. These results are discussed with regard to how beta-catenin interacts with its binding partners and to the potential for identifying specific, small molecule inhibitors of these interactions."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0379"xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0379"xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Miller P.J."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Miller P.J."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Diehl R.E."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Diehl R.E."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Omer C.A."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Omer C.A."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Kral A.M."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/author | "Kral A.M."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/pages | "584-590"xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/pages | "584-590"xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/title | "Identification of Tcf4 residues involved in high-affinity beta-catenin binding."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/title | "Identification of Tcf4 residues involved in high-affinity beta-catenin binding."xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/volume | "256"xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://purl.uniprot.org/core/volume | "256"xsd:string |
| http://purl.uniprot.org/citations/10080941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10080941 |
| http://purl.uniprot.org/citations/10080941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10080941 |