| http://purl.uniprot.org/citations/10092678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10092678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10092678 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated in response to nerve growth factor (NGF) stimulation. Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc, suggesting a model in which competitive binding between FRS-2 and Shc regulates differentiation versus proliferation. Consistent with this model, FRS-2 binds Grb-2, Crk, the SH2 domain containing tyrosine phosphatase SH-PTP-2, the cyclin-dependent kinase substrate p13(suc1), and the Src homology 3 (SH3) domain of Src, providing a functional link between TrkA, cell cycle, and multiple NGF signaling effectors. Importantly, overexpression of FRS-2 in cells expressing an NGF nonresponsive TrkA receptor mutant reconstitutes the ability of NGF to stop cell cycle progression and to stimulate neuronal differentiation."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.14.9861"xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.14.9861"xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Verdi J.M."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Verdi J.M."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Meakin S.O."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Meakin S.O."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Gryz E.A."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Gryz E.A."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Kubu C.J."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "Kubu C.J."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "MacDonald J.I.S."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/author | "MacDonald J.I.S."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/pages | "9861-9870"xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/pages | "9861-9870"xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/title | "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/title | "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10092678 | http://purl.uniprot.org/core/volume | "274"xsd:string |