| http://purl.uniprot.org/citations/10094049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10094049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10094049 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1) is a proinflammatory cytokine that has several effects in the inflammation process. When it binds to its cell-surface receptor, IL-1 initiates a signalling cascade that leads to activation of the transcription factor NF-kappaB and is relayed through the protein TRAF6 and a succession of kinase enzymes, including NF-kappaB-inducing kinase (NIK) and I kappaB kinases (IKKs). However, the molecular mechanism by which NIK is activated is not understood. Here we show that the MAPKK kinase TAK1 acts upstream of NIK in the IL-1-activated signalling pathway and that TAK1 associates with TRAF6 during IL-1 signalling. Stimulation of TAK1 causes activation of NF-kappaB, which is blocked by dominant-negative mutants of NIK, and an inactive TAK1 mutant prevents activation of NF-kappaB that is mediated by IL-1 but not by NIK. Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.org/dc/terms/identifier | "doi:10.1038/18465"xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.org/dc/terms/identifier | "doi:10.1038/18465"xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Hiyama A."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Hiyama A."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Kishimoto K."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Kishimoto K."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/pages | "252-256"xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/pages | "252-256"xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/title | "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/10094049 | http://purl.uniprot.org/core/title | "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."xsd:string |