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http://purl.uniprot.org/citations/10213692http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10213692http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10213692http://www.w3.org/2000/01/rdf-schema#comment"Control of cyclin levels is critical for proper cell cycle regulation. In yeast, the stability of the G1 cyclin Cln1 is controlled by phosphorylation-dependent ubiquitination. Here it is shown that this reaction can be reconstituted in vitro with an SCF E3 ubiquitin ligase complex. Phosphorylated Cln1 was ubiquitinated by SCF (Skp1-Cdc53-F-box protein) complexes containing the F-box protein Grr1, Rbx1, and the E2 Cdc34. Rbx1 promotes association of Cdc34 with Cdc53 and stimulates Cdc34 auto-ubiquitination in the context of Cdc53 or SCF complexes. Rbx1, which is also a component of the von Hippel-Lindau tumor suppressor complex, may define a previously unrecognized class of E3-associated proteins."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.org/dc/terms/identifier"doi:10.1126/science.284.5414.662"xsd:string
http://purl.uniprot.org/citations/10213692http://purl.org/dc/terms/identifier"doi:10.1126/science.284.5414.662"xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Elledge S.J."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Elledge S.J."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Conaway J.W."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Conaway J.W."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Conaway R.C."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Conaway R.C."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Harper J.W."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Harper J.W."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Koepp D.M."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Koepp D.M."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Conrad M.N."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Conrad M.N."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Kamura T."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Kamura T."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Skowyra D."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/author"Skowyra D."xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/10213692http://purl.uniprot.org/core/name"Science"xsd:string