| http://purl.uniprot.org/citations/10219089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10219089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10219089 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-dependent protein kinase (DNA-PK) plays a critical role in resealing DNA double-stand breaks by non-homologous end joining. Aside from DNA-PK, XRCC4 and DNA ligase IV, other proteins which play a role(s) in this repair pathway remain unknown; DNA-PK contains a catalytic subunit (DNA-PKcs) and a DNA binding subunit (Ku70 and Ku80). We isolated Ku70-binding proteins (KUB1-KUB4) using yeast two-hybrid analyses. Sequence analyses revealed KUB1 to be apolipoprotein J (apoJ), also known as X-ray-inducible transcript 8 (XIP8), testosterone-repressed prostate message-2 (TRPM-2) and clusterin. KUB2 is Ku80. KUB3 and KUB4 are unknown, >10 kb trans-cripts. Interactions of apoJ/XIP8 or KUB3 with Ku70 were confirmed by co-immunoprecipitation analyses in MCF-7:WS8 breast cancer or IMR-90 normal lung fibroblast cells, respectively. The interaction of apoJ/XIP8 with Ku70 was confirmed by far-western analyses. Stable over-expression of full-length apoJ/XIP8 in MCF-7:WS8 caused decreased Ku70/Ku80 DNA end binding that was restored by apoJ/XIP8 monoclonal antibodies. The role of apoJ/XIP8 in ionizing radiation resistance/sensitivity is under investigation."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/27.10.2165"xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/27.10.2165"xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Boothman D.A."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Boothman D.A."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Hsu H.L."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Hsu H.L."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Kinsella T.J."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Kinsella T.J."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Leskov K."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Leskov K."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Odegaard E."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Odegaard E."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Yang C.-R."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Yang C.-R."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Yeh S.-Y."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/author | "Yeh S.-Y."xsd:string |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10219089 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |