| http://purl.uniprot.org/citations/10228148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10228148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10228148 | http://www.w3.org/2000/01/rdf-schema#comment | "Bax, a pro-apoptotic member of the Bcl-2 family, translocates from the cytosol to the mitochondria during programmed cell death. We report here that both gain-of-function and loss-of-function mutations can be achieved by altering a single amino acid in the Bax hydrophobic C-terminus. The properly mutated C-terminus of Bax can target a non-relevant protein to the mitochondria, showing that specific conformations of this domain alone allow mitochondrial docking. These data along with N-terminus epitope exposure experiments suggest that the C- and the N-termini interact and that upon triggering of apoptosis, Bax changes conformation, exposing these two domains to insert into the mitochondria and regulate the cell death machinery."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.9.2330"xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.9.2330"xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Smith C.L."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Smith C.L."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Youle R.J."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Youle R.J."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Hsu Y.-T."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Hsu Y.-T."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Nechushtan A."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/author | "Nechushtan A."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/pages | "2330-2341"xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/pages | "2330-2341"xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/title | "Conformation of the Bax C-terminus regulates subcellular location and cell death."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/title | "Conformation of the Bax C-terminus regulates subcellular location and cell death."xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10228148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10228148 |
| http://purl.uniprot.org/citations/10228148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10228148 |