| http://purl.uniprot.org/citations/10228161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10228161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10228161 | http://www.w3.org/2000/01/rdf-schema#comment | "The WD-40 repeat protein FAN binds to a distinct domain of the p55 receptor for tumor necrosis factor (TNF) and signals the activation of neutral sphingomyelinase (N-SMase). To analyze the physiological role of FAN in vivo, we generated FAN-deficient mice by targeted gene disruption. Mice lacking a functional FAN protein do not show any overt phenotypic abnormalities; in particular, the architecture and cellular composition of lymphoid organs appeared to be unaltered. An essential role of FAN in the TNF-induced activation of N-SMase was demonstrated using thymocytes from FAN knockout mice. Activation of extracellular signal-regulated kinases in response to TNF treatment, however, was not impaired by the absence of the FAN protein. FAN-deficient mice show delayed kinetics of recovery after cutaneous barrier disruption suggesting a physiological role of FAN in epidermal barrier repair. Although FAN exhibits striking structural homologies with the CHS/Beige proteins, FAN-deficient mice did not reproduce the phenotype of beige mice."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.9.2472"xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.9.2472"xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Krut O."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Krut O."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Pfeffer K."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Pfeffer K."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Adam-Klages S."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Adam-Klages S."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Kroenke M."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Kroenke M."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Scherer G."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Scherer G."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Jensen J.M."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Jensen J.M."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Kreder D."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Kreder D."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Plitz T."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Plitz T."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Proksch E."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Proksch E."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Steinmann J."xsd:string |
| http://purl.uniprot.org/citations/10228161 | http://purl.uniprot.org/core/author | "Steinmann J."xsd:string |