| http://purl.uniprot.org/citations/10233762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10233762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10233762 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines and their receptors play a crucial part in the recruitment of leukocytes into inflammatory sites. The CXC chemokines IP-10 and Mig are selective attractants for activated (memory) T cells, the predominant cell type in skin infiltrates in many inflammatory dermatoses. The selectivity for activated T cells can be explained by the fact that both chemokines exert their effects through a common receptor, CXCR3, which is nearly exclusively expressed on activated T cells. The aim of this study was to identify biologically active CXCR3 ligands produced by keratinocytes. To that end, Chinese hamster ovary cells expressing a cDNA encoding CXCR3 were challenged with proteins obtained from interferon-gamma stimulated keratinocytes and subsequently monitored for effects on second messenger systems. By this approach we were able to isolate IP-10 and Mig, and in addition identified a novel highly potent ligand for the CXCR3 receptor, designated interferon-gamma-inducible protein-9, which proved to be chemotactic for activated T cells expressing CXCR3. Protein sequence and mass spectrometric analysis followed by molecular cloning of the cDNA encoding interferon-gamma-inducible protein-9, revealed that interferon-gamma-inducible protein-9 is a CXC chemokine with a molecular mass of 8303 Da. From a GenBank database query it became clear that interferon-gamma-inducible protein-9 is in fact the protein encoded by the cDNA sequence also known as beta-R1, H174 or I-TAC. In situ hybridization experiments showed that interferon-gamma-inducible protein-9 mRNA is expressed by basal layer keratinocytes in a variety of skin disorders, including allergic contact dermatitis, lichen planus, and mycosis fungoides suggesting a functional role for this chemokine in skin immune responses."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1523-1747.1999.00581.x"xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1523-1747.1999.00581.x"xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Leurs R."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Leurs R."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Tensen C.P."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Tensen C.P."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Scheper R.J."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Scheper R.J."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "van der Schors R.C."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "van der Schors R.C."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Boorsma D.M."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Boorsma D.M."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Flier J."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Flier J."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Sampat-Sardjoepersad S."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Sampat-Sardjoepersad S."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Willemze R."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "Willemze R."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "van der Raaij-Helmer E.M.H."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/author | "van der Raaij-Helmer E.M.H."xsd:string |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10233762 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |