| http://purl.uniprot.org/citations/10318824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10318824 | http://www.w3.org/2000/01/rdf-schema#comment | "To understand the mechanism of how Axin acts as an inhibitory molecule in the Wnt pathway, we generated a series of mutated forms of Axin. From the binding experiments, we defined the domains of Axin that bind glycogen synthase kinase-3beta (GSK-3beta) and beta-catenin. We also examined the ability of each Axin mutant to inhibit lymphoid enhancer factor-1 (Lef-1) reporter activity in a cell line expressing high levels of beta-catenin. Axin mutants that did not bind GSK-3beta or beta-catenin were ineffective in suppressing Lef-1 reporter activity. Binding GSK-3beta and beta-catenin was not sufficient for this inhibitory effect of Axin. Axin mutants with C-terminal truncations lacked the ability to inhibit Lef-1 reporter activity, even though they bound GSK-3beta and beta-catenin. The C-terminal region was required for binding to Axin itself. Substitution of the C-terminal region with an unrelated dimerizing molecule, the retinoid X receptor restored its inhibitory effect on Lef-1-dependent transcription. The oligomerization of Axin through its C terminus is important for its function in regulation of beta-catenin-mediated response."xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.20.14090"xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/author | "Sakanaka C."xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/author | "Williams L.T."xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/pages | "14090-14093"xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/title | "Functional domains of axin. Importance of the C terminus as an oligomerization domain."xsd:string |
| http://purl.uniprot.org/citations/10318824 | http://purl.uniprot.org/core/volume | "274"xsd:string |
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