| http://purl.uniprot.org/citations/10375506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10375506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10375506 | http://www.w3.org/2000/01/rdf-schema#comment | "XTcf-3 is an HMG box transcription factor that mediates Xenopus dorsal-ventral axis formation. As a Wnt pathway effector, XTcf-3 interacts with beta-catenin and activates the expression of the dorsal organizing gene siamois, while in the absence of beta-catenin, XTcf-3 functions as a transcriptional repressor. We show that XTcf-3 contains amino- and carboxy-terminal repressor domains and have identified a Xenopus member of the C-terminal Binding Protein family of transcriptional co-repressors (XCtBP) as the C-terminal co-repressor. We show that two XCtBP binding sites near the XTcf-3 carboxy-terminus are required for the interaction of XTcf-3 and XCtBP and for the transcriptional repression mediated by the XTcf-3 carboxy-terminal domain. By fusing the GAL4 activation domain to XCtBP we have generated an antimorphic protein, XCtBP/G4A, that activates siamois transcription through an interaction with endogenous XTcf-3. Ectopic expression of XCtBP/G4A demonstrates that XCtBP functions in the regulation of head and notochord development. Our data support a role for XCtBP as a co-repressor throughout Xenopus development and indicate that XCtBP/G4A will be a useful tool in determining how XCtBP functions in various developmental processes."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.14.3159"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.14.3159"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Kimelman D."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Kimelman D."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Brown J.D."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Brown J.D."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Bates R."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Bates R."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Brannon M."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/author | "Brannon M."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/pages | "3159-3170"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/pages | "3159-3170"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/title | "XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/title | "XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development."xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/10375506 | http://purl.uniprot.org/core/volume | "126"xsd:string |