| http://purl.uniprot.org/citations/10377387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10377387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10377387 | http://www.w3.org/2000/01/rdf-schema#comment | "Janus kinases (JAKs) are cytoplasmic tyrosine kinases critical for signaling by growth hormone (GH) and many other ligands that bind to members of the cytokine receptor superfamily. SH2-Bbeta was previously identified as a JAK2-interacting protein that is tyrosyl phosphorylated in response to GH and other cytokines that activate JAK2. In this study, we examined whether SH2-Bbeta alters the activity of JAK2. SH2-Bbeta, when coexpressed with JAK2, significantly increased the tyrosyl phosphorylation of JAK2 and multiple other cellular proteins and stimulated the kinase activity of JAK2 by approximately 20-fold. Coexpression of SH2-Bbeta with JAK2 dramatically increased tyrosyl phosphorylation of signal transducer and activator of transcription (Stat)5B and Stat3, physiological substrates of JAK2. SH2-Bbeta(R555E) with a defective Src homology 2 domain was unable to stimulate JAK2 and JAK2-mediated tyrosyl phosphorylation of Stat5B and Stat3. More importantly, SH2-Bbeta enhanced GH-induced tyrosyl phosphorylation of endogenous JAK2 and ligand-induced tyrosyl phosphorylation of Stat5B by endogenous JAK2. In contrast, SH2-Bbeta did not potentiate the activation of other tyrosine kinases including the receptors for platelet-derived growth factor, epidermal growth factor, or nerve growth factor (TrkA), tyrosine kinases that also bind SH2-Bbeta. These data demonstrate that SH2-Bbeta is a potent cytoplasmic activator of JAK2 and is thereby expected to be an important cellular regulator of signaling by GH and other hormones and cytokines that activate JAK2."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.13.7172"xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.13.7172"xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/author | "Rui L."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/author | "Rui L."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/author | "Carter-Su C."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/author | "Carter-Su C."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/pages | "7172-7177"xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/pages | "7172-7177"xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/title | "Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/title | "Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2."xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10377387 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10377387 |
| http://purl.uniprot.org/citations/10377387 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10377387 |
| http://purl.uniprot.org/citations/10377387 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10377387 |
| http://purl.uniprot.org/citations/10377387 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10377387 |
| http://purl.uniprot.org/uniprot/Q62985 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10377387 |
| http://purl.uniprot.org/uniprot/Q62985#attribution-967FC1343BDA622E2C3B4B0AA74A8022 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10377387 |