| http://purl.uniprot.org/citations/10393185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393185 | http://www.w3.org/2000/01/rdf-schema#comment | "The Pax3-FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t(2;13) (q35;q14) chromosomal translocation. Its oncogenic activity is dependent on a combination of protein-DNA and protein-protein interactions mediated by the Pax3 homeodomain recognition helix. In this report we demonstrate that human Daxx (hDaxx) interacts with Pax3 in vivo and with DNA-bound Pax3 in vitro. This interaction is mediated primarily through the homeodomain recognition helix with the additional involvement of the octapeptide domain and its N-terminal flanking amino acids. Through this interaction hDaxx represses the transcriptional activity of Pax3 by approximately 80%. The Pax3-FKHR fusion is unresponsive to this repressive effect despite an observed endogenous interaction with hDaxx in a rhabdomyosarcoma tumor cell line. Therefore, these data support the model that fusion of FKHR to Pax3 not only adds a strong transactivation domain, but also deregulates transcriptional control of Pax3 by overriding the natural repressive effect of hDaxx."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.13.3702"xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.13.3702"xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "Grosveld G."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "Grosveld G."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "Hollenbach A.D."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "Hollenbach A.D."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "McPherson C.J."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "McPherson C.J."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "Sublett J.E."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/author | "Sublett J.E."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/pages | "3702-3711"xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/pages | "3702-3711"xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/title | "The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/title | "The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx."xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10393185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10393185 |
| http://purl.uniprot.org/citations/10393185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10393185 |