| http://purl.uniprot.org/citations/10395695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10395695 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of the type 1 IL-1R (IL-1R1) and the IL-18R by their cognate ligands induces recruitment of the IL-1R-associated kinase (IRAK). Activation of IRAK leads in turn to nuclear translocation of NF-kappaB, which directs expression of innate and adaptive immune response genes. To study IRAK function in cytokine signaling, we generated cells and mice lacking the IRAK protein. IRAK-deficient fibroblasts show diminished activation of NF-kappaB when stimulated with IL-1. Immune effector cells without IRAK exhibit a defective IFN-gamma response to costimulation with IL-18. Furthermore, mice lacking the Irak gene demonstrate an attenuated response to injected IL-1. Deletion of Irak, however, does not affect the ability of mice to develop delayed-type hypersensitivity or clear infection with the intracellular parasite, Listeria monocytogenes. These results demonstrate that although IRAK participates in IL-1 and IL-18 signal transduction, residual cytokine responsiveness operates through an IRAK-independent pathway."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Thomas J.A."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Wasserman S.A."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Allen J.L."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Danao J."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Liao X.C."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Dubnicoff T."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/author | "Tsen M."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/pages | "978-984"xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/title | "Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase."xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/10395695 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10395695 |
| http://purl.uniprot.org/citations/10395695 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10395695 |
| http://purl.uniprot.org/uniprot/P25799#attribution-7E0E425BC2E9906506956D5F9A34E79B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10395695 |
| http://purl.uniprot.org/uniprot/O88721#attribution-DDDEEC824A17145E4B60094E5180D6BE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10395695 |
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