| http://purl.uniprot.org/citations/10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10421629 | http://www.w3.org/2000/01/rdf-schema#comment | "The stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The dephosphorylated Axin binds beta-catenin less efficiently than the phosphorylated form. Thus, Wnt signaling lowers Axin's affinity for beta-catenin, thereby disengaging beta-catenin from the degradation machinery."xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.13.14.1768"xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/author | "Nusse R."xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/author | "Willert K."xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/author | "Shibamoto S."xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/pages | "1768-1773"xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/title | "Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex."xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/10421629 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10421629 |
| http://purl.uniprot.org/citations/10421629 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10421629 |
| http://purl.uniprot.org/uniprot/#_P56704-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_O15169-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_P49841-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_P62714-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_Q14738-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_Q16537-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_Q14332-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_Q5JTC6-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_O14640-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_O14641-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_O75197-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |
| http://purl.uniprot.org/uniprot/#_O75581-mappedCitation-10421629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10421629 |