| http://purl.uniprot.org/citations/10426995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10426995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10426995 | http://www.w3.org/2000/01/rdf-schema#comment | "The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.285.5428.732"xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.285.5428.732"xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Belisle J.T."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Belisle J.T."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Godowski P.J."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Godowski P.J."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Norgard M.V."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Norgard M.V."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Brennan P.J."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Brennan P.J."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Bleharski J.R."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Bleharski J.R."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Bloom B.R."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Bloom B.R."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Brightbill H.D."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Brightbill H.D."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Krutzik S.R."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Krutzik S.R."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Libraty D.H."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Libraty D.H."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Maitland M."xsd:string |
| http://purl.uniprot.org/citations/10426995 | http://purl.uniprot.org/core/author | "Maitland M."xsd:string |