| http://purl.uniprot.org/citations/10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10442636 | http://www.w3.org/2000/01/rdf-schema#comment | "Individuals affected with neurofibromatosis 1 (NF1) harbor increased numbers of GFAP-immunoreactive cerebral astrocytes and develop astrocytomas that can lead to blindness and death. Mice heterozygous for a targeted Nf1 mutation (Nf1+/-) were employed as a model for the human disease to evaluate the hypothesis that reduced NF1 protein (neurofibromin) expression may confer a growth advantage for astrocytes, such that inactivation of only one NF1 allele is sufficient for abnormal astrocyte proliferation. Here, we report that Nf17+/-mice have increased numbers of cerebral astrocytes and increased astrocyte proliferation compared to wild-type littermates. Intriguingly, primary Nf1+/-astrocyte cultures failed to demonstrate a cell-autonomous growth advantage unless they were cocultured with C17 neuronal cells. This C17 neuronal cell-induced Nf1+/-increase in proliferation was blocked by MEK inhibition (PD98059), suggesting a p21-ras-dependent effect. Furthermore, mice heterozygous for a targeted mutation in another GAP molecule, p120-GAP, demonstrated no increases in cerebral astrocyte number. These findings suggest that reduced NF1 expression results in a cell context-dependent increase in astrocyte proliferation that may be sufficient for the development of astrocytic growth abnormalities in patients with NF1."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202829"xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/author | "Gutmann D.H."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/author | "Henkemeyer M."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/author | "Cashen A."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/author | "Loehr A."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/pages | "4450-4459"xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/title | "Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation."xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10442636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10442636 |
| http://purl.uniprot.org/citations/10442636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10442636 |
| http://purl.uniprot.org/uniprot/Q04690#attribution-97A6D6DEA37D9F824B18349DB0CFD85E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P863-mappedCitation-10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/#_Q3TYD2-mappedCitation-10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/#_Q04690-mappedCitation-10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/#_Q8BQG3-mappedCitation-10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/#_Q5SYH9-mappedCitation-10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/#_Q8CCE8-mappedCitation-10442636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/A0A1W2P863 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10442636 |
| http://purl.uniprot.org/uniprot/Q8CCE8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10442636 |