| http://purl.uniprot.org/citations/10459012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10459012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10459012 | http://www.w3.org/2000/01/rdf-schema#comment | "A more complete picture of the molecules that are critical for the organization of membrane compartments is beginning to emerge through the characterization of proteins in the vesicle-associated membrane protein (also called synaptobrevin) family of membrane trafficking proteins. To better understand the mechanisms of membrane trafficking within the endocytic pathway, we generated a series of monoclonal and polyclonal antibodies against the cytoplasmic domain of vesicle-associated membrane protein 7 (VAMP-7). The antibodies recognize a 25-kD membrane-associated protein in multiple tissues and cell lines. Immunohistochemical analysis reveals colocalization with a marker of late endosomes and lysosomes, lysosome-associated membrane protein 1 (LAMP-1), but not with other membrane markers, including p115 and transferrin receptor. Treatment with nocodozole or brefeldin A does not disrupt the colocalization of VAMP-7 and LAMP-1. Immunoelectron microscopy analysis shows that VAMP-7 is most concentrated in the trans-Golgi network region of the cell as well as late endosomes and transport vesicles that do not contain the mannose-6 phosphate receptor. In streptolysin-O-permeabilized cells, antibodies against VAMP-7 inhibit the breakdown of epidermal growth factor but not the recycling of transferrin. These data are consistent with a role for VAMP-7 in the vesicular transport of proteins from the early endosome to the lysosome."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.146.4.765"xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.146.4.765"xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Lee K.C."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Lee K.C."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Scheller R.H."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Scheller R.H."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Klumperman J."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Klumperman J."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Prekeris R."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Prekeris R."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Advani R.J."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/author | "Advani R.J."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/pages | "765-776"xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/pages | "765-776"xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/title | "VAMP-7 mediates vesicular transport from endosomes to lysosomes."xsd:string |
| http://purl.uniprot.org/citations/10459012 | http://purl.uniprot.org/core/title | "VAMP-7 mediates vesicular transport from endosomes to lysosomes."xsd:string |