| http://purl.uniprot.org/citations/10460238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10460238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10460238 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the Drosophila retinal degeneration B (rdgB) gene cause a rapid loss of the electrophysiological light response and subsequent light-enhanced photoreceptor degeneration. The rdgB gene encodes a protein with an N-terminal phosphatidylinositol transfer protein domain, a large C-terminal segment, and several hydrophobic regions thought to multiply span the subrhabdomeric cisternal membrane. A mammalian rdgB homolog (m-rdgB1) was previously identified and shown to exhibit widespread tissue distribution and functionally rescue the Drosophila rdgB mutant phenotypes. We describe a second mammalian rdgB homolog (m-rdgB2) that possesses 46% amino acid identity to Drosophila RdgB and 56% identity to M-RdgB1. M-RdgB2 possesses a neuronal-specific expression pattern, with high levels in the retina and the dentate gyrus mossy fibers and dendritic field. Using M-RdgB2-specific antibodies and subcellular fractionation, we demonstrate that M-RdgB2 is not an integral membrane protein but is stably associated with a particulate fraction through protein-protein interactions. Although transgenic expression of M-RdgB2 in rdgB2 null mutant flies suppressed the retinal degeneration, it failed to fully restore the electrophysiological light response. Because transgenic expression of M-RdgB2 does not restore the wild-type phenotype to rdgB2 mutant flies to the same extent as M-RdgB1, functional differences likely exist between the two M-RdgB homologs."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-17-07317.1999"xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-17-07317.1999"xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Hyde D.R."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Hyde D.R."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Vihtelic T.S."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/author | "Vihtelic T.S."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/pages | "7317-7325"xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/pages | "7317-7325"xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/title | "A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/title | "A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus."xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10460238 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10460238 |
| http://purl.uniprot.org/citations/10460238 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10460238 |