| http://purl.uniprot.org/citations/10475971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/10475971 | http://www.w3.org/2000/01/rdf-schema#comment | "A search of the National Cancer Institute's Anti-Neoplastic Drug Screen for compounds with an inhibitory profile similar to that of the mitogen-activated protein kinase kinase (MAPKK) inhibitor PD098059 yielded anthrax lethal toxin. Anthrax lethal factor was found to inhibit progesterone-induced meiotic maturation of frog oocytes by preventing the phosphorylation and activation of mitogen-activated protein kinase (MAPK). Similarly, lethal toxin prevented the activation of MAPK in serum stimulated, ras-transformed NIH3T3 cells. In vitro analyses using recombinant proteins indicated that lethal factor proteolytically modified the NH2-terminus of both MAPKK1 and 2, rendering them inactive and hence incapable of activating MAPK. The consequences of this inactivation upon meiosis and transformed cells are also discussed."xsd:string |
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| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/author | "Vande Woude G.F."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/author | "Vande Woude G.F."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/author | "Duesbery N.S."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/author | "Duesbery N.S."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/name | "J. Appl. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/name | "J. Appl. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/pages | "289-293"xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/pages | "289-293"xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/title | "Anthrax lethal factor causes proteolytic inactivation of mitogen-activated protein kinase kinase."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/title | "Anthrax lethal factor causes proteolytic inactivation of mitogen-activated protein kinase kinase."xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/10475971 | http://purl.uniprot.org/core/volume | "87"xsd:string |
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| http://purl.uniprot.org/uniprot/P15917 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10475971 |
| http://purl.uniprot.org/uniprot/P15917#attribution-2B488EFF8DD7FA1C17B1DA313C0095DB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10475971 |