| http://purl.uniprot.org/citations/10488157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10488157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10488157 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of the T cell antigen receptor (TCR) induces tyrosine phosphorylation of numerous intracellular proteins. We have recently investigated the role of the adaptor protein Shb in the early events of T cell signaling and observed that Shb associates with Grb2, linker for activation of T cells (LAT) and the TCR zeta-chain in Jurkat cells. We now report that Shb also associates with phospholipase C-gamma1 (PLC-gamma1) in these cells. Overexpression of Src homology 2 domain defective Shb caused diminished phosphorylation of LAT and consequently the activation of mitogen-activated protein kinases was decreased upon TCR stimulation. In addition, the Shb mutant also blocked phosphorylation of PLC-gamma1 and the increase in cytoplasmic Ca(2+) following TCR stimulation. Nuclear factor for activation of T cells is a major target for Ras and calcium signaling pathways in T cells following TCR stimulation, and the overexpression of the mutant Shb prevented TCR-dependent activation of the nuclear factor for activation of T cells. Consequently, endogenous interleukin-2 production was decreased under these conditions. The results indicate a role for Shb as a link between the TCR and downstream signaling events involving LAT and PLC-gamma1 and resulting in the activation of transcription of the interleukin-2 gene."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.39.28050"xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.39.28050"xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Samelson L.E."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Samelson L.E."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Welsh M."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Welsh M."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Lindholm C.K."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Lindholm C.K."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Gylfe E."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/author | "Gylfe E."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/pages | "28050-28057"xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/pages | "28050-28057"xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/title | "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/title | "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells."xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10488157 | http://purl.uniprot.org/core/volume | "274"xsd:string |