| http://purl.uniprot.org/citations/10518933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10518933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10518933 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, we have shown that the delta subunit of the cGMP phosphodiesterase (PDE delta) interacts with the retinitis pigmentosa guanine regulator (RPGR). Here, using the two-hybrid system, we identify a member of the Arf-like protein family of Ras-related GTP-binding proteins, Arl3, that interacts with PDE delta. The interaction was verified by fluorescence spectroscopy and co-immunoprecipitation. Arl3 features an unusually low affinity for guanine nucleotides, with a KD of 24 nM for GDP and 48 microM for GTP. Fluorescence spectroscopy shows that PDE delta binds and specifically stabilizes the GTP-bound form of Arl3 by strongly decreasing the dissociation rate of GTP. Thus, PDE delta is an effector of Arl3 and could provide a novel nucleotide exchange mechanism by which PDE delta stabilizes Arl3 in its active GTP-bound form."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(99)01117-5"xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(99)01117-5"xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/author | "Becker J."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/author | "Becker J."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/author | "Hanzal-Bayer M."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/author | "Hanzal-Bayer M."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/author | "Linari M."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/author | "Linari M."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/pages | "55-59"xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/pages | "55-59"xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/title | "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/title | "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner."xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/volume | "458"xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://purl.uniprot.org/core/volume | "458"xsd:string |
| http://purl.uniprot.org/citations/10518933 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10518933 |
| http://purl.uniprot.org/citations/10518933 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10518933 |
| http://purl.uniprot.org/citations/10518933 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10518933 |
| http://purl.uniprot.org/citations/10518933 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10518933 |