| http://purl.uniprot.org/citations/10523320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10523320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10523320 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the isolation and molecular characterization of seven distinct proteins present in human [U4/U6.U5] tri-snRNPs. These proteins exhibit clear homology to the Sm proteins and are thus denoted LSm (like Sm) proteins. Purified LSm proteins form a heteromer that is stable even in the absence of RNA and exhibits a doughnut shape under the electron microscope, with striking similarity to the Sm core RNP structure. The purified LSm heteromer binds specifically to U6 snRNA, requiring the 3'-terminal U-tract for complex formation. The 3'-end of U6 snRNA was also co-precipitated with LSm proteins after digestion of isolated tri-snRNPs with RNaseT(1). Importantly, the LSm proteins did not bind to the U-rich Sm sites of intact U1, U2, U4 or U5 snRNAs, indicating that they can only interact with a 3'-terminal U-tract. Finally, we show that the LSm proteins facilitate the formation of U4/U6 RNA duplices in vitro, suggesting that the LSm proteins may play a role in U4/U6 snRNP formation."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.20.5789"xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.20.5789"xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Wilm M."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Wilm M."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Kastner B."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Kastner B."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Bachi A."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Bachi A."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Brahms H."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Brahms H."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Achsel T."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/author | "Achsel T."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/pages | "5789-5802"xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/pages | "5789-5802"xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/title | "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."xsd:string |
| http://purl.uniprot.org/citations/10523320 | http://purl.uniprot.org/core/title | "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."xsd:string |