http://purl.uniprot.org/citations/10524686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10524686 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections.MethodsMBL alleles and serum concentrations were determined by polymerase chain reaction and enzyme-linked immunosorbent assay, respectively, in 91 Danish patients with SLE and in 250 controls.ResultsHomozygosity for MBL variant alleles was observed in 7.7% of the SLE patients compared with 2.8% of the controls (P = 0.06), while no difference was seen for heterozygosity (33.0% versus 34.4%). Homozygotes had an increased risk of acquiring serious infections compared with patients who were heterozygous or homozygous for the normal allele (odds ratio 8.6, 95% confidence interval 1.5-47.6, P = 0.01). The time interval from the diagnosis of SLE to the first infectious event was shorter (P = 0.017), and the annual number of infectious events was 4 times higher, among homozygotes (P = 0.00002). They were especially prone to acquire pneumonia (P = 0.00004). CONCLUSION; Homozygosity for MBL variant alleles may explain much of the increased risk of complicating infections seen in SLE patients. Additionally, it is a minor risk factor for acquiring SLE."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.org/dc/terms/identifier | "doi:10.1002/1529-0131(199910)42:10<2145::aid-anr15>3.0.co;2-#"xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Jacobsen S."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Svejgaard A."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Garred P."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Madsen H.O."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Kronborg G."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Andersen V."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/author | "Halberg P."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/name | "Arthritis Rheum"xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/pages | "2145-2152"xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/title | "Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus."xsd:string |
http://purl.uniprot.org/citations/10524686 | http://purl.uniprot.org/core/volume | "42"xsd:string |
http://purl.uniprot.org/citations/10524686 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10524686 |
http://purl.uniprot.org/citations/10524686 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10524686 |
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http://purl.uniprot.org/uniprot/Q9HCS8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10524686 |
http://purl.uniprot.org/uniprot/B1PN75 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10524686 |