| http://purl.uniprot.org/citations/10531037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10531037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10531037 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin-mediated destruction of regulatory proteins is a frequent means of controlling progression through signaling pathways [1]. F-box proteins [2] are components of modular E3 ubiquitin protein ligases called SCFs, which function in phosphorylation-dependent ubiquitination ([3] [4] [5], reviewed in [6] [7]). F-box proteins contain a carboxy-terminal domain that interacts with substrates and a 42-48 amino-acid F-box motif which binds to the protein Skp1 [2] [3] [4]. Skp1 binding links the F-box protein with a core ubiquitin ligase composed of the proteins Cdc53/Cul1, Rbx1 (also called Hrt1 and Roc1) and the E2 ubiquitin-conjugating enzyme Cdc34 [8] [9] [10] [11]. The genomes of the budding yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans contain, respectively, 16 and more than 60 F-box proteins [2] [7]; in S. cerevisiae, the F-box proteins Cdc4, Grr1 and Met30 target cyclin-dependent kinase inhibitors, G1 cyclins and transcriptional regulators for ubiquitination ([3] [4] [5] [8] [10], reviewed in [6] [7]). Only four mammalian F-box proteins (Cyclin F, Skp1, beta-TRCP and NFB42) have been identified so far [2] [12]. Here, we report the identification of a family of 33 novel mammalian F-box proteins. The large number of these proteins in mammals suggests that the SCF system controls a correspondingly large number of regulatory pathways in vertebrates. Four of these proteins contain a novel conserved motif, the F-box-associated (FBA) domain, which may represent a new protein-protein interaction motif. The identification of these genes will help uncover pathways controlled by ubiquitin-mediated proteolysis in mammals."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)80021-4"xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)80021-4"xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0960-9822(00)80021-4"xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Winston J.T."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Winston J.T."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Koepp D.M."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/author | "Koepp D.M."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/pages | "1180-1182"xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/pages | "1180-1182"xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/title | "A family of mammalian F-box proteins."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/title | "A family of mammalian F-box proteins."xsd:string |
| http://purl.uniprot.org/citations/10531037 | http://purl.uniprot.org/core/volume | "9"xsd:string |