| http://purl.uniprot.org/citations/10542199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10542199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10542199 | http://www.w3.org/2000/01/rdf-schema#comment | "The signaling pathway leading to TGF-beta1-induced apoptosis was investigated using a TGF-beta1-sensitive hepatoma cell line, FaO. Cell cycle analysis demonstrated that the accumulation of apoptotic cells was preceded by a progressive decrease of the cell population in the G(1) phase concomitant with a slight increase of the cell population in the G(2)/M phase in response to TGF-beta1. TGF-beta1 induced a transient increase in the expression of Cdc2, cyclin A, cyclin B, and cyclin D1 at an early phase of apoptosis. During TGF-beta1-induced apoptosis, the transient increase in cyclin-dependent kinase (Cdk) activities coincides with a dramatic increase in the hyperphosphorylated forms of RB. Treatment with roscovitine or olomoucine, inhibitors of Cdc2 and Cdk2, blocked TGF-beta1-induced apoptosis by inhibiting RB phosphorylation. Overexpression of Bcl-2 or adenovirus E1B 19K suppressed TGF-beta1-induced apoptosis by blocking the induction of Cdc2 mRNA and the subsequent activation of Cdc2 kinase, whereas activation of Cdk2 was not affected, suggesting that Cdc2 plays a more critical role in TGF-beta1-induced apoptosis. In conclusion, we present the evidence that Cdc2 and Cdk2 kinase activity transiently induced by TGF-beta1 phosphorylates RB as a physiological target in FaO cells and that RB hyperphosphorylation may trigger abrupt cell cycle progression, leading to irreversible cell death."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.45.31775"xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.45.31775"xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Kim S.-J."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Kim S.-J."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Kang Y."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Kang Y."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Yoon J.-W."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Yoon J.-W."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Choi K.S."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Choi K.S."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Rhee H."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Rhee H."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Eom Y.W."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Eom Y.W."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Ha M.J."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/author | "Ha M.J."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/pages | "31775-31783"xsd:string |
| http://purl.uniprot.org/citations/10542199 | http://purl.uniprot.org/core/pages | "31775-31783"xsd:string |