| http://purl.uniprot.org/citations/10557082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10557082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10557082 | http://www.w3.org/2000/01/rdf-schema#comment | "During development of the vertebrate vascular system essential signals are transduced via protein-tyrosine phosphorylation. Null-mutations of receptor-tyrosine kinase (RTK) genes expressed in endothelial cells (ECs) display early lethal vascular phenotypes. We aimed to identify endothelial protein-tyrosine phosphatases (PTPs), which should have similar importance in EC-biology. A murine receptor-type PTP was identified by a degenerated PCR cloning approach from endothelial cells (VE-PTP). By in situ hybridization this phosphatase was found to be specifically expressed in vascular ECs throughout mouse development. In experiments using GST-fusion proteins, as well as in transient transfections, trapping mutants of VE-PTP co-precipitated with the Angiopoietin receptor Tie-2, but not with the Vascular Endothelial Growth Factor receptor 2 (VEGFR-2/Flk-1). In addition, VE-PTP dephosphorylates Tie-2 but not VEGFR-2. We conclude that VE-PTP is a Tie-2 specific phosphatase expressed in ECs, and VE-PTP phosphatase activity serves to specifically modulate Angiopoietin/Tie-2 function. Based on its potential role as a regulator of blood vessel morphogenesis and maintainance, VE-PTP is a candidate gene for inherited vascular malformations similar to the Tie-2 gene."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202992"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202992"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/author | "Deutsch U."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/author | "Deutsch U."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/author | "Risau W."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/author | "Risau W."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/author | "Fachinger G."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/author | "Fachinger G."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/pages | "5948-5953"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/pages | "5948-5953"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/title | "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/title | "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2."xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10557082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10557082 |
| http://purl.uniprot.org/citations/10557082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10557082 |
| http://purl.uniprot.org/citations/10557082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10557082 |
| http://purl.uniprot.org/citations/10557082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10557082 |