| http://purl.uniprot.org/citations/10558980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10558980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10558980 | http://www.w3.org/2000/01/rdf-schema#comment | "The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, a neurological disorder. The crystal structure of the catalytic hect domain of E6AP reveals a bilobal structure with a broad catalytic cleft at the junction of the two lobes. The cleft consists of conserved residues whose mutation interferes with ubiquitin-thioester bond formation and is the site of Angelman syndrome mutations. The crystal structure of the E6AP hect domain bound to the UbcH7 ubiquitin-conjugating enzyme (E2) reveals the determinants of E2-E3 specificity and provides insights into the transfer of ubiquitin from the E2 to the E3."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.286.5443.1321"xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.286.5443.1321"xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Howley P.M."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Howley P.M."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Huibregtse J.M."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Huibregtse J.M."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Beaudenon S."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Beaudenon S."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Kinnucan E."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/author | "Kinnucan E."xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/pages | "1321-1326"xsd:string |
| http://purl.uniprot.org/citations/10558980 | http://purl.uniprot.org/core/pages | "1321-1326"xsd:string |