| http://purl.uniprot.org/citations/10567410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10567410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10567410 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous recombination plays a fundamental role in DNA double-strand break repair. Previously, we detected two mammalian nuclear proteins of 100 and 75 kDa (POMp100 and POMp75, respectively) that are able to promote homologous DNA pairing, a key step in homologous recombination. Here we describe the identification of human (h) POMp75 as the pro-oncoprotein TLS/FUS. hPOMp75/TLS binds both single- and double-stranded DNAs and mediates annealing of complementary DNA strands. More important, it promotes the uptake of a single-stranded oligonucleotide into a homologous superhelical DNA to form a D-loop. The formation of a D-loop is an essential step in DNA double-strand break repair through recombination. DNA annealing and D-loop formation catalyzed by hPOMp75/TLS require Mg(2+) and are ATP-independent. Interestingly, the oncogenic fusion form TLS-CHOP is not able to promote DNA pairing. These data suggest a possible role for hPOMp75/TLS in maintenance of genomic integrity."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.48.34337"xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.48.34337"xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Sok J."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Sok J."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Lopez B.S."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Lopez B.S."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Akhmedov A.T."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Akhmedov A.T."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Baechtold H."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/author | "Baechtold H."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/pages | "34337-34342"xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/pages | "34337-34342"xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/title | "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation."xsd:string |
| http://purl.uniprot.org/citations/10567410 | http://purl.uniprot.org/core/title | "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation."xsd:string |