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http://purl.uniprot.org/citations/10579999http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10579999http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10579999http://www.w3.org/2000/01/rdf-schema#comment"The RING-H2 finger protein Rbx1 is a subunit of the related SCF (Skp1-Cdc53/Cul1-F-box protein) and von Hippel-Lindau (VHL) tumor suppressor (elongin BC-Cul2-VHL) E3 ubiquitin ligase complexes, where it functions as a component of Cdc53/Rbx1 and Cul2/Rbx1 modules that activate ubiquitination of target proteins by the E2 ubiquitin-conjugating enzymes Cdc34 and Ubc5. Here we demonstrate that the Cdc53/Rbx1 and Cul2/Rbx1 modules also activate conjugation of the ubiquitin-like protein Rub1 to Cdc53 and Cul2 by the dedicated E2 Rub1 conjugating enzyme Ubc12. Our findings identify Rbx1 as a common component of enzyme systems responsible for ubiquitin and Rub1 modification of target proteins."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.org/dc/terms/identifier"doi:10.1101/gad.13.22.2928"xsd:string
http://purl.uniprot.org/citations/10579999http://purl.org/dc/terms/identifier"doi:10.1101/gad.13.22.2928"xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Yan Q."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Yan Q."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Conaway J.W."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Conaway J.W."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Conaway R.C."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Conaway R.C."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Conrad M.N."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Conrad M.N."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Kamura T."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/author"Kamura T."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/name"Genes Dev."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/name"Genes Dev."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/pages"2928-2933"xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/pages"2928-2933"xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/title"The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/title"The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2."xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/10579999http://purl.uniprot.org/core/volume"13"xsd:string