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http://purl.uniprot.org/citations/10589682http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10589682http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10589682http://www.w3.org/2000/01/rdf-schema#comment"The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. The Tube death domain has an insertion between helices 2 and 3, and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface is critical to the activity of these molecules."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)81542-1"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)81542-1"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Xiao T."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Xiao T."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Wasserman S.A."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Wasserman S.A."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Sprang S.R."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Sprang S.R."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Towb P."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/author"Towb P."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/pages"545-555"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/pages"545-555"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/title"Three-dimensional structure of a complex between the death domains of Pelle and Tube."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/title"Three-dimensional structure of a complex between the death domains of Pelle and Tube."xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/volume"99"xsd:string
http://purl.uniprot.org/citations/10589682http://purl.uniprot.org/core/volume"99"xsd:string
http://purl.uniprot.org/citations/10589682http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10589682
http://purl.uniprot.org/citations/10589682http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10589682