| http://purl.uniprot.org/citations/10597216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10597216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10597216 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood. Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein. Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif. Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo. DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis. These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203043"xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203043"xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Inazawa J."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Inazawa J."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Tsujimoto Y."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Tsujimoto Y."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Kamada S."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Kamada S."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Yasuhara N."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/author | "Yasuhara N."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/pages | "6183-6190"xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/pages | "6183-6190"xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/title | "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death."xsd:string |
| http://purl.uniprot.org/citations/10597216 | http://purl.uniprot.org/core/title | "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death."xsd:string |