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| http://purl.uniprot.org/citations/10631167 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt-3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development."xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.127.3.457"xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/author | "McMahon A.P."xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/author | "Tole S."xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/author | "Grove E."xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/pages | "457-467"xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/title | "A local Wnt-3a signal is required for development of the mammalian hippocampus."xsd:string |
| http://purl.uniprot.org/citations/10631167 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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