| http://purl.uniprot.org/citations/10632593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10632593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10632593 | http://www.w3.org/2000/01/rdf-schema#comment | "Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E, a neuropeptide-processing enzyme. These peptides are produced from a single precursor, termed proSAAS, which is present in human, mouse, and rat. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. When expressed in AtT-20 cells, proSAAS is secreted via the regulated pathway and is also processed at paired-basic cleavage sites into smaller peptides. Overexpression of proSAAS in the AtT-20 cells substantially reduces the rate of processing of the endogenous prohormone proopiomelanocortin. Purified proSAAS inhibits prohormone convertase 1 activity with an IC(50) of 590 nM but does not inhibit prohormone convertase 2. Taken together, proSAAS may represent an endogenous inhibitor of prohormone convertase 1."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.20-02-00639.2000"xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.20-02-00639.2000"xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Mzhavia N."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Mzhavia N."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Patterson S.D."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Patterson S.D."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Devi L.A."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Devi L.A."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Courchesne P.L."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Courchesne P.L."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Curran E."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Curran E."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "McKinzie A.A."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "McKinzie A.A."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Douglass J."xsd:string |
| http://purl.uniprot.org/citations/10632593 | http://purl.uniprot.org/core/author | "Douglass J."xsd:string |