| http://purl.uniprot.org/citations/10636902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10636902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10636902 | http://www.w3.org/2000/01/rdf-schema#comment | "The plasminogen activation cascade system, directed by urokinase and the urokinase receptor, plays a key role in extracellular proteolysis during tissue remodeling. To identify molecular interaction partners of these trigger proteins on the cell, we combined covalent protein cross-linking with mass spectrometry based methods for peptide mapping and primary structure analysis of electrophoretically isolated protein conjugates. A specific tri-molecular complex was observed upon addition of pro-urokinase to human U937 cells. This complex included the urokinase receptor, pro-urokinase, and an unknown, high molecular weight urokinase receptor-associated protein. The tryptic peptide mixture derived from a cross-linked complex of pro-urokinase and the latter protein was analyzed by nanoelectrospray tandem mass spectrometric sequencing. This analysis identified the novel protein as the human homologue of a murine membrane-bound lectin with hitherto unknown function. The human cDNA was cloned and sequenced. The protein, designated uPARAP, is a member of the macrophage mannose receptor protein family and contains a putative collagen-binding (fibronectin type II) domain in addition to 8 C-type carbohydrate recognition domains. It proved capable of binding strongly to a single type of collagen, collagen V. This collagen binding reaction at the exact site of plasminogen activation on the cell may lead to adhesive functions as well as a contribution to cellular degradation of collagen matrices."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.3.1993"xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.3.1993"xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Jensen O.N."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Jensen O.N."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Behrendt N."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Behrendt N."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Moertz E."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Moertz E."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Engelholm L.H."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Engelholm L.H."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Danoe K."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/author | "Danoe K."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/pages | "1993-2002"xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/pages | "1993-2002"xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/title | "A urokinase receptor-associated protein with specific collagen binding properties."xsd:string |
| http://purl.uniprot.org/citations/10636902 | http://purl.uniprot.org/core/title | "A urokinase receptor-associated protein with specific collagen binding properties."xsd:string |