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| http://purl.uniprot.org/citations/10644691 | http://www.w3.org/2000/01/rdf-schema#comment | "The Dishevelled (Dvl) gene family encodes cytoplasmic proteins that are necessary for Wnt signal transduction. Utilizing the yeast two-hybrid system, we identified protein phosphatase 2Calpha (PP2C) as a Dvl-PDZ domain-interacting protein. PP2C exists in a complex with Dvl, beta-catenin, and Axin, a negative regulator of Wnt signaling. In a Wnt-responsive LEF-1 reporter gene assay, expression of PP2C activates transcription and also elicits a synergistic response with beta-catenin and Wnt-1. In addition, PP2C expression relieves Axin-mediated repression of LEF-1-dependent transcription. PP2C utilizes Axin as a substrate both in vitro and in vivo and decreases its half-life. These results indicate that PP2C is a positive regulator of Wnt signal transduction and mediates its effects through the dephosphorylation of Axin."xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.4.2399"xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/author | "Sussman D.J."xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/author | "Strovel E.T."xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/pages | "2399-2403"xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/title | "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."xsd:string |
| http://purl.uniprot.org/citations/10644691 | http://purl.uniprot.org/core/volume | "275"xsd:string |
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