http://purl.uniprot.org/citations/10650002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10650002 | http://www.w3.org/2000/01/rdf-schema#comment | "Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/-fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.287.5453.664"xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Harding H.P."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Chung P."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Bertolotti A."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/author | "Urano F."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/pages | "664-666"xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/title | "Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1."xsd:string |
http://purl.uniprot.org/citations/10650002 | http://purl.uniprot.org/core/volume | "287"xsd:string |
http://purl.uniprot.org/citations/10650002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10650002 |
http://purl.uniprot.org/citations/10650002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10650002 |
http://purl.uniprot.org/uniprot/Q9EQY0#attribution-7F20B0CB8B32C61AEA2D9F28070C0EF8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/O75460#attribution-BC53542B2980A1E4A17A9440B7509B79 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/Q9Z2E3#attribution-BC53542B2980A1E4A17A9440B7509B79 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/Q12933#attribution-BEF88CD6007E840E2A01AB4AABF5A0F6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/Q12933#attribution-FADCB063E5814729DB1BA4E00D1AC3D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/B5DFH7#attribution-FADCB063E5814729DB1BA4E00D1AC3D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/#_A0A0G2K2H4-mappedCitation-10650002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10650002 |
http://purl.uniprot.org/uniprot/#_A0A8I6A2F5-mappedCitation-10650002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10650002 |