| http://purl.uniprot.org/citations/10652313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10652313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10652313 | http://www.w3.org/2000/01/rdf-schema#comment | "We have used NMR methods to determine the structure of the calcium complex of complement-like repeat 3 (CR3) from the low density lipoprotein receptor-related protein (LRP) and to examine its specific interaction with the receptor binding domain of human alpha(2)-macroglobulin. CR3 is one of eight related repeats that constitute a major ligand binding region of LRP. The structure is very similar in overall fold to homologous complement-like repeat CR8 from LRP and complement-like repeats LB1, LB2, and LB5 from the low density lipoprotein receptor and contains a short two-strand antiparallel beta-sheet, a one turn alpha-helix, and a high affinity calcium site with coordination from four carboxyls and two backbone carbonyls. The surface electrostatics and topography are, however, quite distinct from each of these other repeats. Two-dimensional (1)H,(15)N-heteronuclear single quantum coherence spectra provide evidence for a specific, though relatively weak (K(d) approximately 140 microM), interaction between CR3 and human alpha2-macroglobulin receptor binding domain that involves a contiguous patch of surface residues in the central region of CR3. This specific interaction is consistent with a mode of LRP binding to ligands that uses contributions from more than one domain to generate a wide array of different binding sites, each with overall high affinity."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.5.3264"xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.5.3264"xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/author | "Dolmer K."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/author | "Dolmer K."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/author | "Gettins P.G.W."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/author | "Gettins P.G.W."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/pages | "3264-3269"xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/pages | "3264-3269"xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/title | "NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/title | "NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin."xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10652313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10652313 |
| http://purl.uniprot.org/citations/10652313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10652313 |
| http://purl.uniprot.org/citations/10652313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10652313 |
| http://purl.uniprot.org/citations/10652313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10652313 |