| http://purl.uniprot.org/citations/10653850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10653850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10653850 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T(h)1 response. IL-18 has a structural homology to IL-1, particularly IL-1beta. IL-18R, composed of IL-1R-related protein (IL-18Ralpha) and IL-1R accessory protein-like (IL-18Rbeta), belongs to the IL-1R family. Furthermore, IL-18R at least partly shares the signal transducing system with IL-1R. Thus, the IL-18-IL-18R system has a striking similarity to the IL-1-IL-1R system. For this reason, we regarded it important to investigate whether, like IL-18, IL-1beta synergizes with IL-12 in inducing IFN-gamma production from human T cells and plays an important role in the T(h)1 response. Here we show that IL-12 and IL-1beta synergistically induce T cells to proliferate and produce IFN-gamma without their TCR engagement. IL-12 stimulation induced an increase in the proportion of T cells positive for IL-18R. Then, IL-12-stimulated T cells responded to IL-18 or IL-1beta by their proliferation and IFN-gamma production, although levels of IL-1beta-induced responses were lower. CD4(+)CD45RA(+) T cells, although they constitutively expressed IL-18Rbeta mRNA, did not express IL-18Ralpha mRNA. Phytohemagglutinin (PHA) stimulation alone induced IL-18Ralpha mRNA without affecting the expression of IL-18Rbeta mRNA. T(h)1-inducing conditions (PHA, IL-12 and anti-IL-4) further increased this expression. We also show that T(h)1 cells but not T(h)2 cells have increased expression of IL-18R and IL-1R, and produce IFN-gamma in response to IL-18 and/or IL-1beta."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/12.2.151"xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/12.2.151"xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Kurimoto M."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Kurimoto M."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Matsui K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Matsui K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Yoshimoto T."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Yoshimoto T."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Nakanishi K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Nakanishi K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Torigoe K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Torigoe K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Okamura H."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Okamura H."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Tominaga K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Tominaga K."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Hada T."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/author | "Hada T."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/name | "Int. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10653850 | http://purl.uniprot.org/core/name | "Int. Immunol."xsd:string |