| http://purl.uniprot.org/citations/10692421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10692421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10692421 | http://www.w3.org/2000/01/rdf-schema#comment | "Post-translational modification marked by the covalent attachment of the ubiquitin-like protein SUMO-1/SMT3C has been implicated in a wide variety of cellular processes. Recently, two cDNAs encoding proteins related to SUMO-1 have been identified in human and mouse. The functions and regulation of these proteins, known as SUMO-2/SMT3A and SUMO-3/SMT3B, remain largely uncharacterized. We describe herein quantitative and qualitative distinctions between SUMO-1 and SUMO-2/3 in vertebrate cells. Much of this was accomplished through the application of an antibody that recognizes SUMO-2 and -3, but not SUMO-1. This antibody detected multiple SUMO-2/3-modified proteins and revealed that, together, SUMO-2 and -3 constitute a greater percentage of total cellular protein modification than does SUMO-1. Intriguingly, we found that there was a large pool of free, non-conjugated SUMO-2/3 and that the conjugation of SUMO-2/3 to high molecular mass proteins was induced when the cells were subjected to protein-damaging stimuli such as acute temperature fluctuation. In addition, we demonstrated that SUMO-2/3 conjugated poorly, if at all, to a major SUMO-1 substrate, the Ran GTPase-activating protein RanGAP1. Together, these results support the concept of important distinctions between the SUMO-2/3 and SUMO-1 conjugation pathways and suggest a role for SUMO-2/3 in the cellular responses to environmental stress."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.9.6252"xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.9.6252"xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/author | "Saitoh H."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/author | "Saitoh H."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/author | "Hinchey J."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/author | "Hinchey J."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/pages | "6252-6258"xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/pages | "6252-6258"xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/title | "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/title | "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3."xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10692421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10692421 |
| http://purl.uniprot.org/citations/10692421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10692421 |
| http://purl.uniprot.org/citations/10692421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10692421 |
| http://purl.uniprot.org/citations/10692421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10692421 |
| http://purl.uniprot.org/uniprot/P55854 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10692421 |
| http://purl.uniprot.org/uniprot/P61956 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10692421 |