| http://purl.uniprot.org/citations/10693759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10693759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10693759 | http://www.w3.org/2000/01/rdf-schema#comment | "Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In Drosophila, Ci action as transcriptional repressor or activator is contingent upon Hedgehog-regulated, PKA-dependent proteolytic processing. We demonstrate that PKA-dependent processing of vertebrate Gli3 in developing limb similarly generates a potent repressor in a manner antagonized by apparent long-range signaling from posteriorly localized Sonic hedgehog protein. The resulting anterior/posterior Gli3 repressor gradient can be perturbed by mutations of Gli3 in human genetic syndromes or by misregulation of Gli3 processing in the chicken mutant talpid2, producing a range of limb patterning malformations. The high relative abundance and potency of Gli3 repressor suggest specialization of Gli3 and its products for negative Hedgehog pathway regulation."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80678-9"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80678-9"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/author | "Beachy P.A."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/author | "Beachy P.A."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/author | "Fallon J.F."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/author | "Fallon J.F."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/pages | "423-434"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/pages | "423-434"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/title | "Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/title | "Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb."xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/10693759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10693759 |
| http://purl.uniprot.org/citations/10693759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10693759 |
| http://purl.uniprot.org/citations/10693759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10693759 |
| http://purl.uniprot.org/citations/10693759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10693759 |