http://purl.uniprot.org/citations/10707087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10707087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10707087 | http://www.w3.org/2000/01/rdf-schema#comment | "Major-histocompatibility-complex (MHC) proteins are used to display, on the surface of a cell, peptides derived from foreign material - such as a virus - that is infecting that cell. Cytotoxic T lymphocytes then recognize and kill the infected cell. The HIV-1 Nef protein downregulates the cell-surface expression of class I MHC proteins, and probably thereby promotes immune evasion by HIV-1. In the presence of Nef, class I MHC molecules are relocalized from the cell surface to the trans-Golgi network (TGN) through as-yet-unknown mechanisms. Here we show that Nef-induced downregulation of MHC-I expression and MHC-I targeting to the TGN require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin. This interaction is dependent on Nef's cluster of acidic amino acids. A chimaeric integral membrane protein containing Nef as its cytoplasmic domain localizes to the TGN after internalization, in an acidic-cluster- and PACS-1-dependent manner. These results support a model in which Nef relocalizes MHC-I by acting as a connector between MHC-I's cytoplasmic tail and the PACS-1-dependent protein-sorting pathway."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.org/dc/terms/identifier | "doi:10.1038/35004038"xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.org/dc/terms/identifier | "doi:10.1038/35004038"xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Wan L."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Wan L."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Borel C."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Borel C."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Trono D."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Trono D."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Demaurex N."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Demaurex N."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Mangasarian A."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Mangasarian A."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Piguet V."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/author | "Piguet V."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/pages | "163-167"xsd:string |
http://purl.uniprot.org/citations/10707087 | http://purl.uniprot.org/core/pages | "163-167"xsd:string |