| http://purl.uniprot.org/citations/10716937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10716937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10716937 | http://www.w3.org/2000/01/rdf-schema#comment | "The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal. The mechanism of MPF nuclear localization remains unclear since it contains no functional nuclear localization signal (NLS). We exploited the yeast two-hybrid screen to find protein(s) potentially mediating localization of cyclin B1 and identified a novel interaction between cyclin B1 and cyclin F. We found that cdc2, cyclin B1 and cyclin F form a complex that exhibits histone H1 kinase activity. Cyclin B1 and cyclin F also colocalize through immunofluorescence studies. Additionally, deletion analysis revealed that each putative NLS of cyclin F is functional. Taken together, the data suggest that the NLS regions of cyclin F regulate cyclin B1 localization to the nucleus. The interaction between cyclin B1 and cyclin F represents the first example of direct cyclin-cyclin binding, and elucidates a novel mechanism that regulates MPF localization and function."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.6.1378"xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.6.1378"xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Donoghue D.J."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Donoghue D.J."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Ollendorff V."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Ollendorff V."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Barnes E.A."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Barnes E.A."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Kong M."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/author | "Kong M."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/pages | "1378-1388"xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/pages | "1378-1388"xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/title | "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/title | "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction."xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10716937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10716937 |
| http://purl.uniprot.org/citations/10716937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10716937 |